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GLP-1 receptor activation directly engages this same pathway

One rat study found sublingual semaglutide achieved a 5-fold higher blood concentration compared to oral administration at the same dose

They concluded that incretin-based medications did not correlate with an increased risk of acute pancreatitis or pancreatic cancer compared to other oral anti-diabetic agents, which remained consistent across drug classification and duration of use [29,55]

Effects of the once-weekly glucagon-like peptide-1 receptor agonist dulaglutide on ambulatory blood pressure and heart rate in patients with type 2 diabetes mellitus